Drug interactions
Desflurane + Vemurafenib
Severity: Moderate
Desflurane and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way. Desflurane also affects repolarization, so the combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Desflurane and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before anesthesia. Monitor the ECG during the procedure and avoid adding other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Vemurafenib
Frequently asked questions
Can I take Desflurane with Vemurafenib?
MediHelp rates the interaction as moderate. Desflurane and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QT interval in a concentration-dependent way. Desflurane also affects repolarization, so the combination may raise the risk of torsades de pointes.
How serious is the interaction between Desflurane and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before anesthesia. Monitor the ECG during the procedure and avoid adding other QT-prolonging agents.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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