Drug interactions
Desflurane + Vorinostat
Severity: Moderate
Desflurane and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been linked to QT prolongation, and desflurane can also delay repolarization. Combined use may increase the risk of ventricular arrhythmias, particularly with electrolyte disturbances.
What this interaction means in plain words
Desflurane and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Correct potassium and magnesium and obtain a baseline ECG before anesthesia. Monitor the ECG intraoperatively and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Desflurane with Vorinostat?
MediHelp rates the interaction as moderate. Desflurane and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been linked to QT prolongation, and desflurane can also delay repolarization. Combined use may increase the risk of ventricular arrhythmias, particularly with electrolyte disturbances.
How serious is the interaction between Desflurane and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and obtain a baseline ECG before anesthesia. Monitor the ECG intraoperatively and avoid other QT-prolonging drugs.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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