Drug interactions
Desipramine + Dihydroergotamine
Severity: Moderate
Desipramine and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, so the combination may increase the risk of serotonin syndrome. Ergot-related vasoconstriction may also be affected, though the main concern is additive serotonergic toxicity.
What this interaction means in plain words
Desipramine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from reuptake inhibition and serotonin receptor agonism.
What to do
Monitor for agitation, tremor, hyperthermia and neuromuscular signs when combining. Stop one agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Desipramine with Dihydroergotamine?
MediHelp rates the interaction as moderate. Desipramine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, so the combination may increase the risk of serotonin syndrome. Ergot-related vasoconstriction may also be affected, though the main concern is additive serotonergic toxicity.
How serious is the interaction between Desipramine and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and neuromuscular signs when combining. Stop one agent if serotonin syndrome is suspected.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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