Drug interactions
Desipramine + Eletriptan
Severity: Moderate
Desipramine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a tricyclic antidepressant with a triptan can theoretically increase serotonergic activity, and serotonin syndrome has been reported with such combinations. The risk appears low in practice.
What this interaction means in plain words
Desipramine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition by desipramine and 5-HT1B/1D agonism by eletriptan.
What to do
Counsel patients to report agitation, tremor, sweating, diarrhea or fever, and monitor for serotonin toxicity after starting or increasing either drug. Stop one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Desipramine with Eletriptan?
MediHelp rates the interaction as moderate. Desipramine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a tricyclic antidepressant with a triptan can theoretically increase serotonergic activity, and serotonin syndrome has been reported with such combinations. The risk appears low in practice.
How serious is the interaction between Desipramine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, diarrhea or fever, and monitor for serotonin toxicity after starting or increasing either drug. Stop one agent if symptoms develop.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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