Drug interactions
Desipramine + Estradiol
Severity: Minor
Desipramine and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant concentrations and adverse effects, while the antidepressant effect may in some cases be reduced. The reports are limited and the effect varies between patients.
What this interaction means in plain words
Desipramine and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Estradiol belongs to Endocrine.
Why it happens
Possible estrogen-related alteration of tricyclic metabolism; the mechanism is not well established.
What to do
Monitor for tricyclic adverse effects such as sedation, dry mouth and tachycardia, and for loss of antidepressant response when estrogen is started or stopped. Adjust the desipramine dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Desipramine with Estradiol?
MediHelp rates the interaction as minor. Desipramine and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant concentrations and adverse effects, while the antidepressant effect may in some cases be reduced. The reports are limited and the effect varies between patients.
How serious is the interaction between Desipramine and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as sedation, dry mouth and tachycardia, and for loss of antidepressant response when estrogen is started or stopped. Adjust the desipramine dose accordingly.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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