Drug interactions
Desipramine + Fedratinib
Severity: Moderate
Desipramine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP2D6 inhibitor and can raise desipramine concentrations, as desipramine is cleared mainly through CYP2D6. Higher levels may increase anticholinergic effects, sedation, and cardiac conduction and QT effects.
What this interaction means in plain words
Desipramine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated metabolism of desipramine by fedratinib.
What to do
Monitor for tricyclic toxicity and consider a lower desipramine dose, guided by plasma levels or ECG when available. Reassess the dose when fedratinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Desipramine with Fedratinib?
MediHelp rates the interaction as moderate. Desipramine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP2D6 inhibitor and can raise desipramine concentrations, as desipramine is cleared mainly through CYP2D6. Higher levels may increase anticholinergic effects, sedation, and cardiac conduction and QT effects.
How serious is the interaction between Desipramine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider a lower desipramine dose, guided by plasma levels or ECG when available. Reassess the dose when fedratinib is stopped.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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