Drug interactions
Desipramine + Goserelin
Severity: Moderate
Desipramine and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Goserelin lowers testosterone and can prolong the QT interval, and desipramine also has QT-prolonging potential at higher exposures. Together they may add to the risk of ventricular arrhythmias, especially in patients with other risk factors.
What this interaction means in plain words
Desipramine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation, with androgen deprivation by goserelin and cardiac ion channel effects of desipramine.
What to do
Obtain a baseline ECG and repeat it after treatment starts, and correct potassium and magnesium abnormalities. Reconsider the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Desipramine with Goserelin?
MediHelp rates the interaction as moderate. Desipramine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Goserelin lowers testosterone and can prolong the QT interval, and desipramine also has QT-prolonging potential at higher exposures. Together they may add to the risk of ventricular arrhythmias, especially in patients with other risk factors.
How serious is the interaction between Desipramine and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after treatment starts, and correct potassium and magnesium abnormalities. Reconsider the combination if the QTc becomes markedly prolonged.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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