Drug interactions
Desipramine + Indacaterol
Severity: Major
Desipramine and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and themselves prolong the QT interval. Concurrent use may increase the risk of palpitations, tachycardia and ventricular arrhythmias.
What this interaction means in plain words
Desipramine and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Tricyclic-related QT prolongation and enhanced adrenergic cardiovascular response add to the effects of indacaterol.
What to do
Avoid the combination where an alternative exists, otherwise obtain an ECG and monitor heart rate and potassium. Reduce the desipramine dose or switch agents if QTc lengthens or arrhythmia symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Indacaterol?
MediHelp rates the interaction as major. Desipramine and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and themselves prolong the QT interval. Concurrent use may increase the risk of palpitations, tachycardia and ventricular arrhythmias.
How serious is the interaction between Desipramine and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists, otherwise obtain an ECG and monitor heart rate and potassium. Reduce the desipramine dose or switch agents if QTc lengthens or arrhythmia symptoms develop.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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