Drug interactions
Desipramine + Midodrine
Severity: Moderate
Desipramine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist, and tricyclics can enhance adrenergic responses by blocking norepinephrine reuptake. This may cause excessive blood pressure elevation, particularly supine hypertension, or bradycardia.
What this interaction means in plain words
Desipramine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive adrenergic pressor effects due to norepinephrine reuptake inhibition combined with direct alpha-1 agonism.
What to do
Monitor supine and standing blood pressure and heart rate after starting or adjusting either drug. Reduce the midodrine dose if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Desipramine with Midodrine?
MediHelp rates the interaction as moderate. Desipramine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist, and tricyclics can enhance adrenergic responses by blocking norepinephrine reuptake. This may cause excessive blood pressure elevation, particularly supine hypertension, or bradycardia.
How serious is the interaction between Desipramine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and heart rate after starting or adjusting either drug. Reduce the midodrine dose if hypertension occurs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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