Drug interactions
Desipramine + Mirtazapine
Severity: Moderate
Desipramine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antidepressants can prolong the QT interval, and together they may increase arrhythmia risk, especially with other risk factors. Additive sedation and some serotonergic effects are also possible.
What this interaction means in plain words
Desipramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and overlapping CNS and serotonergic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor the QTc and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Desipramine with Mirtazapine?
MediHelp rates the interaction as moderate. Desipramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antidepressants can prolong the QT interval, and together they may increase arrhythmia risk, especially with other risk factors. Additive sedation and some serotonergic effects are also possible.
How serious is the interaction between Desipramine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor the QTc and avoid adding other QT-prolonging drugs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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