Drug interactions
Desipramine + Ozanimod
Severity: Major
Desipramine and Ozanimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
An ozanimod metabolite inhibits MAO-B, so combination with a tricyclic that increases norepinephrine and serotonin may cause hypertension or serotonin toxicity. Labeling advises against use with such drugs.
What this interaction means in plain words
Desipramine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
MAO inhibition by an ozanimod metabolite combined with desipramine reuptake inhibition may increase monoamine levels.
What to do
Avoid the combination where possible; if used, monitor blood pressure and for signs of serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Desipramine with Ozanimod?
MediHelp rates the interaction as major. Desipramine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. An ozanimod metabolite inhibits MAO-B, so combination with a tricyclic that increases norepinephrine and serotonin may cause hypertension or serotonin toxicity. Labeling advises against use with such drugs.
How serious is the interaction between Desipramine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor blood pressure and for signs of serotonin syndrome.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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