Drug interactions
Desipramine + Pregabalin
Severity: Moderate
Desipramine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause drowsiness, dizziness and cognitive slowing, and together they may deepen CNS depression. Falls and respiratory depression are more likely in older or medically frail patients and when other sedatives are present.
What this interaction means in plain words
Desipramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depressant effects.
What to do
Use the lowest effective doses and titrate gradually while monitoring for sedation and respiratory depression. Warn patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Desipramine with Pregabalin?
MediHelp rates the interaction as moderate. Desipramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause drowsiness, dizziness and cognitive slowing, and together they may deepen CNS depression. Falls and respiratory depression are more likely in older or medically frail patients and when other sedatives are present.
How serious is the interaction between Desipramine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate gradually while monitoring for sedation and respiratory depression. Warn patients about driving and alcohol.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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