Drug interactions
Desipramine + Propylhexedrine
Severity: Moderate
Desipramine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant, and tricyclics can alter its effects. The combination may cause hypertension, tachycardia or arrhythmia, although systemic exposure at normal doses is limited.
What this interaction means in plain words
Desipramine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Desipramine blocks norepinephrine reuptake and uptake of indirect sympathomimetics into adrenergic neurons.
What to do
Limit propylhexedrine to the labeled dose and duration. Monitor blood pressure and heart rate and use a non-sympathomimetic alternative if cardiovascular symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Desipramine with Propylhexedrine?
MediHelp rates the interaction as moderate. Desipramine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an inhaled sympathomimetic decongestant, and tricyclics can alter its effects. The combination may cause hypertension, tachycardia or arrhythmia, although systemic exposure at normal doses is limited.
How serious is the interaction between Desipramine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit propylhexedrine to the labeled dose and duration. Monitor blood pressure and heart rate and use a non-sympathomimetic alternative if cardiovascular symptoms occur.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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