Drug interactions
Desipramine + Sevoflurane
Severity: Moderate
Desipramine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval and causes CNS depression, and desipramine can add to these effects. Perioperative arrhythmias and hemodynamic instability are the main concerns.
What this interaction means in plain words
Desipramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depressant effects.
What to do
Inform the anesthesia team and review a baseline ECG. Monitor the ECG and hemodynamics during and after anesthesia, and keep electrolytes in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Desipramine with Sevoflurane?
MediHelp rates the interaction as moderate. Desipramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval and causes CNS depression, and desipramine can add to these effects. Perioperative arrhythmias and hemodynamic instability are the main concerns.
How serious is the interaction between Desipramine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and review a baseline ECG. Monitor the ECG and hemodynamics during and after anesthesia, and keep electrolytes in the normal range.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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