Drug interactions
Desipramine + Stiripentol
Severity: Moderate
Desipramine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so combined use may deepen sedation and impair alertness. Stiripentol is also a CYP inhibitor and may raise desipramine exposure, increasing the risk of tricyclic adverse effects.
What this interaction means in plain words
Desipramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible inhibition of CYP2D6/CYP1A2-mediated desipramine metabolism by stiripentol.
What to do
Monitor for excessive sedation and anticholinergic or cardiac effects when starting or changing doses. Consider desipramine plasma level monitoring and dose reduction if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Desipramine with Stiripentol?
MediHelp rates the interaction as moderate. Desipramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so combined use may deepen sedation and impair alertness. Stiripentol is also a CYP inhibitor and may raise desipramine exposure, increasing the risk of tricyclic adverse effects.
How serious is the interaction between Desipramine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and anticholinergic or cardiac effects when starting or changing doses. Consider desipramine plasma level monitoring and dose reduction if toxicity appears.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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