Drug interactions
Desipramine + Tedizolid
Severity: Moderate
Desipramine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine inhibits norepinephrine and, less so, serotonin reuptake, while tedizolid weakly inhibits MAO. A serotonergic or noradrenergic interaction is theoretical, with little clinical evidence of harm.
What this interaction means in plain words
Desipramine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive monoaminergic effect from weak MAO inhibition plus reuptake inhibition.
What to do
The combination can be used if needed; monitor for symptoms of serotonin toxicity and for blood pressure elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Tedizolid?
MediHelp rates the interaction as moderate. Desipramine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine inhibits norepinephrine and, less so, serotonin reuptake, while tedizolid weakly inhibits MAO. A serotonergic or noradrenergic interaction is theoretical, with little clinical evidence of harm.
How serious is the interaction between Desipramine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used if needed; monitor for symptoms of serotonin toxicity and for blood pressure elevation.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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