Drug interactions
Desipramine + Tiotropium-olodaterol
Severity: Moderate
Desipramine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a tricyclic antidepressant with anticholinergic activity that adds to tiotropium. It also prolongs the QT interval and can potentiate the cardiovascular effects of beta2 agonists, increasing the risk of arrhythmias.
What this interaction means in plain words
Desipramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive cardiac effects (QT prolongation, adrenergic stimulation).
What to do
Monitor for anticholinergic effects and palpitations, and obtain an ECG in patients with cardiac disease. Correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Desipramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a tricyclic antidepressant with anticholinergic activity that adds to tiotropium. It also prolongs the QT interval and can potentiate the cardiovascular effects of beta2 agonists, increasing the risk of arrhythmias.
How serious is the interaction between Desipramine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and palpitations, and obtain an ECG in patients with cardiac disease. Correct electrolyte disturbances.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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