Drug interactions
Desloratadine + Lomitapide
Severity: Minor
Desloratadine and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may raise exposure to P-gp substrates such as desloratadine. The wide therapeutic margin of desloratadine makes a clinically important effect unlikely.
What this interaction means in plain words
Desloratadine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of desloratadine by lomitapide.
What to do
No routine adjustment is needed. Monitor for increased antihistamine adverse effects and reduce the desloratadine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Desloratadine with Lomitapide?
MediHelp rates the interaction as minor. Desloratadine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein and may raise exposure to P-gp substrates such as desloratadine. The wide therapeutic margin of desloratadine makes a clinically important effect unlikely.
How serious is the interaction between Desloratadine and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for increased antihistamine adverse effects and reduce the desloratadine dose if they occur.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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