Drug interactions
Desloratadine + Lurasidone
Severity: Minor
Desloratadine and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone often causes somnolence, and desloratadine can occasionally cause fatigue or drowsiness. Combined use could slightly increase sedation.
What this interaction means in plain words
Desloratadine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no established pharmacokinetic interaction.
What to do
Monitor for added drowsiness and advise caution with driving. No dose change is typically required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Desloratadine with Lurasidone?
MediHelp rates the interaction as minor. Desloratadine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurasidone often causes somnolence, and desloratadine can occasionally cause fatigue or drowsiness. Combined use could slightly increase sedation.
How serious is the interaction between Desloratadine and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for added drowsiness and advise caution with driving. No dose change is typically required.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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