Drug interactions
Desogestrel-ethinyl estradiol + Posaconazole
Severity: Moderate
Desogestrel-ethinyl estradiol and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and can raise ethinyl estradiol and progestin concentrations. This may increase estrogenic adverse effects such as nausea, breast tenderness and possibly thrombotic risk.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated hepatic and intestinal metabolism of ethinyl estradiol and desogestrel.
What to do
Monitor for estrogen-related adverse effects during azole therapy and reassess the need for the contraceptive if prolonged treatment is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Posaconazole?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits CYP3A4 and can raise ethinyl estradiol and progestin concentrations. This may increase estrogenic adverse effects such as nausea, breast tenderness and possibly thrombotic risk.
How serious is the interaction between Desogestrel-ethinyl estradiol and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects during azole therapy and reassess the need for the contraceptive if prolonged treatment is required.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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