Drug interactions
Desogestrel-ethinyl estradiol + Teriflunomide
Severity: Moderate
Desogestrel-ethinyl estradiol and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide increases ethinyl estradiol exposure modestly. This may amplify estrogenic adverse effects, and teriflunomide is teratogenic so reliable contraception is essential.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Possible inhibition of BCRP or CYP1A2-related pathways raising ethinyl estradiol levels; mechanism not firmly established.
What to do
Choose the contraceptive dose with this effect in mind and monitor for estrogenic adverse effects; maintain effective contraception throughout and after teriflunomide treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desogestrel-ethinyl estradiol and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Teriflunomide?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide increases ethinyl estradiol exposure modestly. This may amplify estrogenic adverse effects, and teriflunomide is teratogenic so reliable contraception is essential.
How serious is the interaction between Desogestrel-ethinyl estradiol and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose the contraceptive dose with this effect in mind and monitor for estrogenic adverse effects; maintain effective contraception throughout and after teriflunomide treatment.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
