Drug interactions
Desvenlafaxine + Lisdexamfetamine
Severity: Major
Desvenlafaxine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serotonergic and monoaminergic activity, so combining them can lead to serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. They may also increase blood pressure and heart rate.
What this interaction means in plain words
Desvenlafaxine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desvenlafaxine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from reuptake inhibition (desvenlafaxine) and amphetamine-induced monoamine release.
What to do
If combined, start with low doses and titrate slowly while monitoring for serotonin toxicity and blood pressure. Stop the serotonergic agents if serotonin syndrome occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Lisdexamfetamine?
MediHelp rates the interaction as major. Desvenlafaxine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise serotonergic and monoaminergic activity, so combining them can lead to serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. They may also increase blood pressure and heart rate.
How serious is the interaction between Desvenlafaxine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, start with low doses and titrate slowly while monitoring for serotonin toxicity and blood pressure. Stop the serotonergic agents if serotonin syndrome occurs.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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