Drug interactions
Desvenlafaxine + Metoclopramide
Severity: Moderate
Desvenlafaxine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide combined with a serotonin-norepinephrine reuptake inhibitor may increase the risk of serotonin syndrome. Extrapyramidal effects and rarely neuroleptic malignant syndrome are also possible.
What this interaction means in plain words
Desvenlafaxine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive serotonergic effects together with dopamine D2 receptor antagonism by metoclopramide.
What to do
Limit metoclopramide to the lowest dose and shortest duration, and watch for hyperreflexia, clonus, fever, agitation and dystonia. Discontinue metoclopramide if signs of serotonin toxicity or extrapyramidal symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Metoclopramide?
MediHelp rates the interaction as moderate. Desvenlafaxine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide combined with a serotonin-norepinephrine reuptake inhibitor may increase the risk of serotonin syndrome. Extrapyramidal effects and rarely neuroleptic malignant syndrome are also possible.
How serious is the interaction between Desvenlafaxine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit metoclopramide to the lowest dose and shortest duration, and watch for hyperreflexia, clonus, fever, agitation and dystonia. Discontinue metoclopramide if signs of serotonin toxicity or extrapyramidal symptoms develop.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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