Drug interactions
Deutetrabenazine + Fluconazole
Severity: Moderate
Deutetrabenazine and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole prolongs the QT interval, and deutetrabenazine can add to this risk in patients with predisposing factors or when other QT-prolonging drugs are present. At usual doses, deutetrabenazine has little effect on QT alone, so the combined risk is modest.
What this interaction means in plain words
Deutetrabenazine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation, mainly relevant in predisposed patients.
What to do
Correct potassium and magnesium abnormalities and consider an ECG in patients with bradycardia, congenital long QT or other QT-prolonging drugs. Avoid the combination in those at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Fluconazole?
MediHelp rates the interaction as moderate. Deutetrabenazine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole prolongs the QT interval, and deutetrabenazine can add to this risk in patients with predisposing factors or when other QT-prolonging drugs are present. At usual doses, deutetrabenazine has little effect on QT alone, so the combined risk is modest.
How serious is the interaction between Deutetrabenazine and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium abnormalities and consider an ECG in patients with bradycardia, congenital long QT or other QT-prolonging drugs. Avoid the combination in those at high risk.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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