Drug interactions
Deutetrabenazine + Goserelin
Severity: Moderate
Deutetrabenazine and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Goserelin may prolong QT through androgen deprivation, while deutetrabenazine has only small QT effects at recommended doses. Combined use adds modest risk that is greater with bradycardia, electrolyte disturbance or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG in patients with risk factors and correct potassium and magnesium. Repeat the ECG if symptoms such as syncope or palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Goserelin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Goserelin may prolong QT through androgen deprivation, while deutetrabenazine has only small QT effects at recommended doses. Combined use adds modest risk that is greater with bradycardia, electrolyte disturbance or congenital long QT.
How serious is the interaction between Deutetrabenazine and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG in patients with risk factors and correct potassium and magnesium. Repeat the ECG if symptoms such as syncope or palpitations occur.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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