Drug interactions
Deutetrabenazine + Mirtazapine
Severity: Moderate
Deutetrabenazine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, although the effect of deutetrabenazine at usual doses is small. The risk is greater with other contributing factors such as electrolyte disturbance, bradycardia or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Possible additive QT interval prolongation; deutetrabenazine may also add to sedation and depression-related effects.
What to do
Obtain an ECG and correct potassium and magnesium in patients with additional QT risk factors. Monitor for syncope or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Mirtazapine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, although the effect of deutetrabenazine at usual doses is small. The risk is greater with other contributing factors such as electrolyte disturbance, bradycardia or congenital long QT.
How serious is the interaction between Deutetrabenazine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium in patients with additional QT risk factors. Monitor for syncope or palpitations.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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