Drug interactions
Deutetrabenazine + Ondansetron
Severity: Moderate
Deutetrabenazine and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron prolongs the QT interval in a dose-related way. Deutetrabenazine has little QT effect at recommended doses, but may add a small effect at higher exposures, so risk is mostly relevant with other risk factors such as bradycardia or low potassium.
What this interaction means in plain words
Deutetrabenazine and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Possible additive QT prolongation.
What to do
Correct potassium and magnesium before treatment and avoid high ondansetron doses. Consider an ECG in patients with long QT, bradycardia or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Ondansetron?
MediHelp rates the interaction as moderate. Deutetrabenazine and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ondansetron prolongs the QT interval in a dose-related way. Deutetrabenazine has little QT effect at recommended doses, but may add a small effect at higher exposures, so risk is mostly relevant with other risk factors such as bradycardia or low potassium.
How serious is the interaction between Deutetrabenazine and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before treatment and avoid high ondansetron doses. Consider an ECG in patients with long QT, bradycardia or other QT-prolonging drugs.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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