Drug interactions
Deutetrabenazine + Risperidone
Severity: Major
Deutetrabenazine and Risperidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect dopaminergic transmission, so combined use may raise the risk of parkinsonism, akathisia, sedation and neuroleptic malignant syndrome. Each can also contribute to QT prolongation, although deutetrabenazine has little effect at recommended doses.
What this interaction means in plain words
Deutetrabenazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deutetrabenazine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism (D2 blockade plus VMAT2 inhibition) with additive sedation and possible QT effects.
What to do
Monitor closely for extrapyramidal symptoms, sedation and signs of neuroleptic malignant syndrome. Consider an ECG if other QT risk factors exist, and use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Risperidone?
MediHelp rates the interaction as major. Deutetrabenazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs affect dopaminergic transmission, so combined use may raise the risk of parkinsonism, akathisia, sedation and neuroleptic malignant syndrome. Each can also contribute to QT prolongation, although deutetrabenazine has little effect at recommended doses.
How serious is the interaction between Deutetrabenazine and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for extrapyramidal symptoms, sedation and signs of neuroleptic malignant syndrome. Consider an ECG if other QT risk factors exist, and use the lowest effective doses.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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