Drug interactions
Deutetrabenazine + Sevoflurane
Severity: Moderate
Deutetrabenazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval, and deutetrabenazine may add a small effect, especially with higher exposures. Clinically significant risk is mainly in patients with additional risk factors for torsades de pointes.
What this interaction means in plain words
Deutetrabenazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before surgery. Monitor ECG during anesthesia in patients with bradycardia, electrolyte problems or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Sevoflurane?
MediHelp rates the interaction as moderate. Deutetrabenazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval, and deutetrabenazine may add a small effect, especially with higher exposures. Clinically significant risk is mainly in patients with additional risk factors for torsades de pointes.
How serious is the interaction between Deutetrabenazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before surgery. Monitor ECG during anesthesia in patients with bradycardia, electrolyte problems or other QT-prolonging drugs.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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