Drug interactions
Deutetrabenazine + Trazodone
Severity: Moderate
Deutetrabenazine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong the QT interval, and deutetrabenazine has a small effect at higher exposure. Together with risk factors this may increase the chance of torsades de pointes. Both drugs also contribute to sedation and depression-related concerns.
What this interaction means in plain words
Deutetrabenazine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation and additive CNS effects.
What to do
Consider baseline and follow-up ECG in patients with cardiac risk factors and correct potassium and magnesium disturbances. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Trazodone?
MediHelp rates the interaction as moderate. Deutetrabenazine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong the QT interval, and deutetrabenazine has a small effect at higher exposure. Together with risk factors this may increase the chance of torsades de pointes. Both drugs also contribute to sedation and depression-related concerns.
How serious is the interaction between Deutetrabenazine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and follow-up ECG in patients with cardiac risk factors and correct potassium and magnesium disturbances. Avoid adding further QT-prolonging drugs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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