Drug interactions
Dexamethasone + Enzalutamide
Severity: Moderate
Dexamethasone and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially reduce dexamethasone exposure, potentially weakening its effect. Dexamethasone is also a CYP3A4 inducer and may lower enzalutamide exposure to a lesser degree.
What this interaction means in plain words
Dexamethasone and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Enzalutamide belongs to Endocrine.
Why it happens
Strong induction of CYP3A4 by enzalutamide increases dexamethasone clearance.
What to do
Monitor clinical response to dexamethasone and increase the dose if the effect is inadequate, particularly when used for antiemetic or replacement indications.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Dexamethasone with Enzalutamide?
MediHelp rates the interaction as moderate. Dexamethasone and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially reduce dexamethasone exposure, potentially weakening its effect. Dexamethasone is also a CYP3A4 inducer and may lower enzalutamide exposure to a lesser degree.
How serious is the interaction between Dexamethasone and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dexamethasone and increase the dose if the effect is inadequate, particularly when used for antiemetic or replacement indications.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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