Drug interactions
Dexamethasone + Perampanel
Severity: Moderate
Dexamethasone and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may reduce perampanel concentrations, potentially reducing seizure control. The effect is likely smaller than with carbamazepine or phenytoin.
What this interaction means in plain words
Dexamethasone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Perampanel belongs to Central Nervous System.
Why it happens
Dexamethasone induces CYP3A4, which contributes to perampanel oxidative metabolism.
What to do
Monitor seizure control when dexamethasone is started or stopped, and titrate perampanel according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Dexamethasone with Perampanel?
MediHelp rates the interaction as moderate. Dexamethasone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may reduce perampanel concentrations, potentially reducing seizure control. The effect is likely smaller than with carbamazepine or phenytoin.
How serious is the interaction between Dexamethasone and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control when dexamethasone is started or stopped, and titrate perampanel according to response.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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