Drug interactions
Dexamethasone + Tepotinib
Severity: Minor
Dexamethasone and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein, which may modestly increase systemic dexamethasone exposure. Dexamethasone has a wide therapeutic window, so clinically significant effects are uncommon.
What this interaction means in plain words
Dexamethasone and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal P-gp, reducing efflux of dexamethasone, which is a P-gp substrate.
What to do
No dose change is usually required. Monitor for corticosteroid adverse effects such as hyperglycemia during prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Dexamethasone with Tepotinib?
MediHelp rates the interaction as minor. Dexamethasone and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein, which may modestly increase systemic dexamethasone exposure. Dexamethasone has a wide therapeutic window, so clinically significant effects are uncommon.
How serious is the interaction between Dexamethasone and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for corticosteroid adverse effects such as hyperglycemia during prolonged therapy.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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