Drug interactions
Dexamethasone + Tucatinib
Severity: Moderate
Dexamethasone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and can raise dexamethasone exposure, increasing corticosteroid adverse effects. Dexamethasone, a CYP3A inducer, may also lower tucatinib exposure and efficacy.
What this interaction means in plain words
Dexamethasone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing dexamethasone clearance, while dexamethasone induces CYP3A4 and may reduce tucatinib levels.
What to do
Monitor for steroid toxicity such as hyperglycemia and fluid retention, and consider reducing the dexamethasone dose. Avoid prolonged dexamethasone where possible and monitor tucatinib response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Dexamethasone with Tucatinib?
MediHelp rates the interaction as moderate. Dexamethasone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and can raise dexamethasone exposure, increasing corticosteroid adverse effects. Dexamethasone, a CYP3A inducer, may also lower tucatinib exposure and efficacy.
How serious is the interaction between Dexamethasone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for steroid toxicity such as hyperglycemia and fluid retention, and consider reducing the dexamethasone dose. Avoid prolonged dexamethasone where possible and monitor tucatinib response.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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