Drug interactions
Dexamethasone + Ubrogepant
Severity: Moderate
Dexamethasone and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak to moderate CYP3A4 inducer and may lower ubrogepant exposure. Reduced exposure may lessen the benefit in acute migraine.
What this interaction means in plain words
Dexamethasone and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Ubrogepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases the metabolism of ubrogepant, a CYP3A4 substrate.
What to do
Use the higher ubrogepant dose of 100 mg for the initial dose if the label permits with weak or moderate inducers, and monitor efficacy. Consider alternatives if prolonged dexamethasone therapy reduces response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Dexamethasone with Ubrogepant?
MediHelp rates the interaction as moderate. Dexamethasone and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is a weak to moderate CYP3A4 inducer and may lower ubrogepant exposure. Reduced exposure may lessen the benefit in acute migraine.
How serious is the interaction between Dexamethasone and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the higher ubrogepant dose of 100 mg for the initial dose if the label permits with weak or moderate inducers, and monitor efficacy. Consider alternatives if prolonged dexamethasone therapy reduces response.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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