Drug interactions
Dexamethasone-neomycin-polymyxin + Perampanel
Severity: Minor
Dexamethasone-neomycin-polymyxin and Perampanel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and slightly reduce perampanel levels, potentially affecting seizure control. Topical use gives minimal exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Perampanel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Perampanel belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by dexamethasone increases perampanel metabolism.
What to do
Monitor seizure control if systemic dexamethasone is started or stopped, and adjust perampanel if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Perampanel?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Perampanel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and slightly reduce perampanel levels, potentially affecting seizure control. Topical use gives minimal exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Perampanel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control if systemic dexamethasone is started or stopped, and adjust perampanel if needed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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