Drug interactions
Dexamethasone-neomycin-polymyxin + Posaconazole
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and may increase systemic dexamethasone exposure, raising corticosteroid adverse effects. Relevance is greatest with systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, reducing dexamethasone metabolism.
What to do
Monitor for steroid adverse effects such as hyperglycemia and adrenal suppression, and reduce dexamethasone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Posaconazole?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits CYP3A4 and may increase systemic dexamethasone exposure, raising corticosteroid adverse effects. Relevance is greatest with systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for steroid adverse effects such as hyperglycemia and adrenal suppression, and reduce dexamethasone dose if needed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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