Drug interactions
Dexchlorpheniramine + Lurasidone
Severity: Minor
Dexchlorpheniramine and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating first-generation antihistamine with anticholinergic activity. With lurasidone it may cause additive drowsiness and reduced psychomotor performance.
What this interaction means in plain words
Dexchlorpheniramine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexchlorpheniramine belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from antihistamine and antipsychotic properties.
What to do
Counsel patients about drowsiness and avoiding driving or alcohol. Consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Lurasidone?
MediHelp rates the interaction as minor. Dexchlorpheniramine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexchlorpheniramine is a sedating first-generation antihistamine with anticholinergic activity. With lurasidone it may cause additive drowsiness and reduced psychomotor performance.
How serious is the interaction between Dexchlorpheniramine and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoiding driving or alcohol. Consider a non-sedating antihistamine as an alternative.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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