Drug interactions
Dexchlorpheniramine + Meperidine
Severity: Moderate
Dexchlorpheniramine and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine and adds to opioid-induced drowsiness and psychomotor impairment. Anticholinergic effects may also accumulate, causing confusion or urinary retention in susceptible patients.
What this interaction means in plain words
Dexchlorpheniramine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Counsel on sedation and avoid driving. Reduce doses where needed and monitor older adults closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Meperidine?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating antihistamine and adds to opioid-induced drowsiness and psychomotor impairment. Anticholinergic effects may also accumulate, causing confusion or urinary retention in susceptible patients.
How serious is the interaction between Dexchlorpheniramine and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving. Reduce doses where needed and monitor older adults closely.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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