Drug interactions
Dexchlorpheniramine + Pentazocine
Severity: Moderate
Dexchlorpheniramine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating first-generation antihistamine. With pentazocine it can cause additive drowsiness, psychomotor impairment and anticholinergic effects.
What this interaction means in plain words
Dexchlorpheniramine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid activity and H1 antihistamine blockade.
What to do
Monitor sedation, especially in elderly patients, and advise avoiding driving and alcohol. Use a non-sedating antihistamine if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexchlorpheniramine and Pentazocine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Pentazocine?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating first-generation antihistamine. With pentazocine it can cause additive drowsiness, psychomotor impairment and anticholinergic effects.
How serious is the interaction between Dexchlorpheniramine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, especially in elderly patients, and advise avoiding driving and alcohol. Use a non-sedating antihistamine if feasible.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
