Drug interactions
Dexlansoprazole + Digoxin
Severity: Minor
Dexlansoprazole and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs may modestly raise digoxin absorption and serum concentrations, mainly of concern in patients at risk of digoxin toxicity.
What this interaction means in plain words
Dexlansoprazole and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Digoxin belongs to Cardiovascular.
Why it happens
Raised gastric pH may increase digoxin absorption.
What to do
Monitor digoxin levels and toxicity signs in higher-risk patients when starting or stopping dexlansoprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Dexlansoprazole with Digoxin?
MediHelp rates the interaction as minor. Dexlansoprazole and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. PPIs may modestly raise digoxin absorption and serum concentrations, mainly of concern in patients at risk of digoxin toxicity.
How serious is the interaction between Dexlansoprazole and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and toxicity signs in higher-risk patients when starting or stopping dexlansoprazole.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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