Drug interactions
Dexlansoprazole + Fedratinib
Severity: Minor
Dexlansoprazole and Fedratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is cleared partly by CYP3A4 and CYP2C19. Dexlansoprazole is a substrate of these enzymes and only a weak inhibitor, so any rise in fedratinib exposure is theoretical and has not been studied. Higher fedratinib levels could increase toxicity such as gastrointestinal effects, myelosuppression and Wernicke encephalopathy.
What this interaction means in plain words
Dexlansoprazole and Fedratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Fedratinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP2C19/CYP3A4 by dexlansoprazole reducing fedratinib clearance; not established clinically.
What to do
No dose change is generally required. Monitor for fedratinib adverse effects and thiamine status as per routine fedratinib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Dexlansoprazole with Fedratinib?
MediHelp rates the interaction as minor. Dexlansoprazole and Fedratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is cleared partly by CYP3A4 and CYP2C19. Dexlansoprazole is a substrate of these enzymes and only a weak inhibitor, so any rise in fedratinib exposure is theoretical and has not been studied. Higher fedratinib levels could increase toxicity such as gastrointestinal effects, myelosuppression and Wernicke encephalopathy.
How serious is the interaction between Dexlansoprazole and Fedratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor for fedratinib adverse effects and thiamine status as per routine fedratinib care.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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