Drug interactions
Dexlansoprazole + Idelalisib
Severity: Minor
Dexlansoprazole and Idelalisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase dexlansoprazole concentrations. Dexlansoprazole has a wide safety margin, so the increase is rarely harmful. The caution for sensitive CYP3A substrates mainly concerns narrow-therapeutic-index drugs.
What this interaction means in plain words
Dexlansoprazole and Idelalisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition by idelalisib decreasing dexlansoprazole metabolism.
What to do
No dose change is usually necessary. Monitor for PPI adverse effects during prolonged high-dose use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Idelalisib?
MediHelp rates the interaction as minor. Dexlansoprazole and Idelalisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A inhibitor and may increase dexlansoprazole concentrations. Dexlansoprazole has a wide safety margin, so the increase is rarely harmful. The caution for sensitive CYP3A substrates mainly concerns narrow-therapeutic-index drugs.
How serious is the interaction between Dexlansoprazole and Idelalisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually necessary. Monitor for PPI adverse effects during prolonged high-dose use.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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