Drug interactions
Dexlansoprazole + Stiripentol
Severity: Moderate
Dexlansoprazole and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and CYP3A4 and may also induce some enzymes, so dexlansoprazole exposure may change unpredictably. The clinical effect is likely modest but may affect acid control.
What this interaction means in plain words
Dexlansoprazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 and CYP3A4, altering dexlansoprazole metabolism.
What to do
Monitor for adverse effects or lost acid control and adjust the dexlansoprazole dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Dexlansoprazole with Stiripentol?
MediHelp rates the interaction as moderate. Dexlansoprazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19 and CYP3A4 and may also induce some enzymes, so dexlansoprazole exposure may change unpredictably. The clinical effect is likely modest but may affect acid control.
How serious is the interaction between Dexlansoprazole and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects or lost acid control and adjust the dexlansoprazole dose as needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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