Drug interactions
Dexmedetomidine + Hydroxyzine
Severity: Moderate
Dexmedetomidine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is sedating and may enhance dexmedetomidine sedation, raising the risk of oversedation. Both drugs may also affect cardiac conduction, hydroxyzine through QT prolongation and dexmedetomidine through bradycardia.
What this interaction means in plain words
Dexmedetomidine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression through alpha-2 agonism and central H1 antagonism.
What to do
Monitor sedation, heart rate and ECG when risk factors for QT prolongation exist, and reduce the dexmedetomidine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Dexmedetomidine with Hydroxyzine?
MediHelp rates the interaction as moderate. Dexmedetomidine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is sedating and may enhance dexmedetomidine sedation, raising the risk of oversedation. Both drugs may also affect cardiac conduction, hydroxyzine through QT prolongation and dexmedetomidine through bradycardia.
How serious is the interaction between Dexmedetomidine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and ECG when risk factors for QT prolongation exist, and reduce the dexmedetomidine dose if needed.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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