Drug interactions
Dexmedetomidine + Iloprost
Severity: Moderate
Dexmedetomidine and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use may cause additive hypotension, particularly with intravenous iloprost. Dexmedetomidine can also cause bradycardia.
What this interaction means in plain words
Dexmedetomidine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Iloprost belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and alpha-2 mediated sympatholysis.
What to do
Monitor blood pressure and heart rate continuously during co-administration. Reduce the iloprost or dexmedetomidine rate if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Dexmedetomidine with Iloprost?
MediHelp rates the interaction as moderate. Dexmedetomidine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use may cause additive hypotension, particularly with intravenous iloprost. Dexmedetomidine can also cause bradycardia.
How serious is the interaction between Dexmedetomidine and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during co-administration. Reduce the iloprost or dexmedetomidine rate if hypotension develops.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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