Drug interactions
Dexmedetomidine + Temazepam
Severity: Moderate
Dexmedetomidine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic and, together with dexmedetomidine, can increase sedation and respiratory depression. Impaired psychomotor function and hypotension may also occur.
What this interaction means in plain words
Dexmedetomidine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and alpha-2 agonism.
What to do
Use reduced doses and monitor sedation level, respiratory rate and oxygen saturation. Titrate dexmedetomidine to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Dexmedetomidine with Temazepam?
MediHelp rates the interaction as moderate. Dexmedetomidine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic and, together with dexmedetomidine, can increase sedation and respiratory depression. Impaired psychomotor function and hypotension may also occur.
How serious is the interaction between Dexmedetomidine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor sedation level, respiratory rate and oxygen saturation. Titrate dexmedetomidine to effect.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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