Drug interactions
Dexmethylphenidate + Dextroamphetamine
Severity: Moderate
Dexmethylphenidate and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are CNS stimulants that increase catecholamine activity. Together they may cause greater increases in heart rate and blood pressure, insomnia, anxiety and appetite suppression. Combining two stimulants is generally unnecessary.
What this interaction means in plain words
Dexmethylphenidate and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmethylphenidate belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Additive dopaminergic and noradrenergic stimulation.
What to do
Avoid concurrent use unless specifically intended by a specialist. If used, monitor blood pressure, heart rate, sleep and mood.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexmethylphenidate and Dextroamphetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Dextroamphetamine?
MediHelp rates the interaction as moderate. Dexmethylphenidate and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are CNS stimulants that increase catecholamine activity. Together they may cause greater increases in heart rate and blood pressure, insomnia, anxiety and appetite suppression. Combining two stimulants is generally unnecessary.
How serious is the interaction between Dexmethylphenidate and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless specifically intended by a specialist. If used, monitor blood pressure, heart rate, sleep and mood.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
