Drug interactions
Dexmethylphenidate + Phenelzine
Severity: Contraindicated
Dexmethylphenidate and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate with MAO inhibitors may cause hypertensive crisis. Severe headache, very high blood pressure and cerebrovascular events are possible.
What this interaction means in plain words
Dexmethylphenidate and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition increases catecholamine stores, and dexmethylphenidate increases synaptic catecholamines, producing an exaggerated pressor response.
What to do
Do not use during phenelzine therapy or within 14 days of stopping it. Select a non-stimulant alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dexmethylphenidate + Selegiline Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Phenelzine?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dexmethylphenidate with MAO inhibitors may cause hypertensive crisis. Severe headache, very high blood pressure and cerebrovascular events are possible.
How serious is the interaction between Dexmethylphenidate and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during phenelzine therapy or within 14 days of stopping it. Select a non-stimulant alternative.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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