Drug interactions
Dexmethylphenidate + Rasagiline
Severity: Contraindicated
Dexmethylphenidate and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants such as dexmethylphenidate given with MAO inhibitors may cause hypertensive crisis. Labeling contraindicates use during and for 14 days after MAO inhibitor therapy.
What this interaction means in plain words
Dexmethylphenidate and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Dexmethylphenidate increases synaptic catecholamines and MAO inhibition prevents their breakdown, causing additive pressor effects.
What to do
Avoid the combination and separate by at least 14 days after stopping the MAO inhibitor. Use a non-stimulant alternative if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dexmethylphenidate + Selegiline Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Rasagiline?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Stimulants such as dexmethylphenidate given with MAO inhibitors may cause hypertensive crisis. Labeling contraindicates use during and for 14 days after MAO inhibitor therapy.
How serious is the interaction between Dexmethylphenidate and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and separate by at least 14 days after stopping the MAO inhibitor. Use a non-stimulant alternative if needed.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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